Hyperbaric Oxygen Therapy (HBOT) involves breathing concentrated oxygen in a gently pressurised environment. The combination of increased pressure and higher oxygen concentration allows oxygen to dissolve more efficiently into blood plasma and body tissues.

HBOT is used globally across medical, athletic, and wellness settings. Epigenedit applies mild hyperbaric oxygen therapy within a wellness and longevity-focused framework, designed to support the body’s natural physiological processes.

In everyday life, we breathe air containing approximately 21% oxygen at normal atmospheric pressure. Inside Epigenedit’s hyperbaric oxygen chamber, you breathe pressurised concentrated oxygen at 95%.

Under these conditions, oxygen dissolves more readily into blood plasma, enabling it to reach tissues with lower circulation and supporting cellular energy production, recovery, and resilience.

Clients commonly use Epigenedit HBOT to support:

• Longevity and healthy ageing
• Energy levels and vitality
• Mental clarity and cognitive performance
• Physical recovery and resilience
• Reduction of inflammation
• Immune system support
• Skin health and natural rejuvenation

The Epigenedit chamber is designed to support overall wellbeing and quality of life rather than to diagnose, treat, cure, or prevent medical conditions.

While protocols can be personalised, a commonly recommended foundational approach is:

• 3–5 sessions per week
• 60–90 minutes per session
• A minimum of 20–30 sessions

This initial phase allows oxygen efficiency at a cellular level to improve and stabilise. After completing a foundational series, we recommend users continue with weekly maintenance sessions to help sustain oxygen utilisation, resilience, and long-term benefits.

Consistency is key for meaningful and lasting results.

Epigenedit was founded in Switzerland with the goal of creating a soft-shell hyperbaric chamber that meets Swiss principles of precision, reliability and safety.

After extensive global research, we found that many soft-shell chambers did not meet our expectations for protocol accuracy, materials, and user experience. As a result, Epigenedit developed a system with several unique features:

Integrated automatic protocol timer

The chamber includes a built-in interval timer that automatically follows recognised oxygen protocols – typically 20 minutes of pressurised oxygen followed by a 5-minute break. This removes the need for users to manually track time during sessions and supports protocol consistency.

Material quality and manufacturing oversight

We personally audited our soft-shell chamber manufacturer, widely regarded for producing high-quality TPU plastics and welded materials used in hyperbaric applications. All materials are biocompatible, non-toxic, and engineered for durability and comfort.

The Epigenedit Hyperbaric Oxygen Chamber is paired with the PRO 10 Oxygen Concentrator and Compressor, a medical-grade oxygen system used within a wellness application.

The PRO 10 is designed and manufactured to medical-device standards and provides reliable, high-purity oxygen delivery.

Key features include:

• Oxygen flow rates from 1–10 litres per minute
• Oxygen purity of approximately 95%
• Designed for continuous operation
• Built-in oxygen sensing device (OSD)
• Visual and audible safety alarms
• Multi-stage filtration
• Quiet operation suitable for home or clinic environments

While the Epigenedit chamber itself is classified for wellness use, the PRO 10 oxygen system meets medical-grade manufacturing and safety standards, supporting reliability, consistency, and long-term use.

European oxygen technology partnership

Epigenedit partners with Pro O2, an established oxygen technology provider with operations in Germany and the United States.

Pro O2 designs and manufactures oxygen systems to meet strict European and international medical-device standards. Their broader manufacturing heritage includes long-standing involvement in advanced medical equipment used in clinical and hospital environments.

Their parent company, Nidek, is globally recognised for producing sophisticated medical and diagnostic devices.

This partnership ensures the highest standards of health and safety in oxygen delivery.

Medical hyperbaric chambers

• Are regulated medical devices
• Typically hard-shell systems
• Operate at higher pressures (often ≥2.0 ATA)
• Used in hospitals or specialist clinics
• Require medical supervision and prescriptions

Non-medical (wellness) hyperbaric chambers, such as Epigenedit:

• Operate at mild hyperbaric pressures (1.3–1.5 ATA)
• Are intended for wellness, longevity, recovery, and performance support
• Are suitable for home and wellness environments
• Do not claim to treat medical conditions

A wellness chamber may still incorporate medical-grade components, such as oxygen concentrators and compressors, without being classified as a medical treatment device.

Most people describe the experience as calm and relaxing.

During pressurisation, mild ear pressure may occur – similar to the sensation experienced during airplane take-off or landing. This usually resolves within minutes. Once pressurised, breathing feels normal and many users read, meditate, or rest comfortably.

Individual responses vary.

Some people report relaxation during the session and a sense of calm or mental clarity afterwards. Others notice more subtle effects over time. Research and experience suggest that benefits are cumulative, with consistency playing an important role in outcomes.

Health span refers to the number of years lived in good health. Emerging human research suggests that structured HBOT protocols may influence biological markers associated with ageing, inflammation balance, vascular function, and cognitive performance.

Evidence supporting HBOT and health span

Bryan Johnson – 90-day HBOT self-experiment

Bryan Johnson completed 60 hyperbaric oxygen therapy sessions in 90 days, tracking a wide range of biological markers. Reported outcomes included:

• Inflammation markers (hsCRP) falling below detectable limits
• VEGF (vascular endothelial growth factor) increased by ~300%, indicating enhanced blood vessel formation and oxygen efficiency
• Telomerase activity measured at 7.7%, a level typically seen in much younger individuals
• pTAU-217 reduced by 28.6%, a biomarker associated with neurodegeneration
• Gut microbiome improvements, including a ~250% increase in short-chain fatty acids (SCFAs) and the return of Akkermansia muciniphila, a bacterium associated with metabolic and longevity health

While this was a self-experiment, it represents one of the most data-rich publicly shared HBOT protocols to date.

Cellular ageing & immune rejuvenation – Clinical trials led by Shai Efrati

Research led by Shai Efrati and colleagues studied older adults undergoing structured HBOT protocols. Key published findings include:

• Telomere length increased by 20–38% across several immune cell types
• Senescent (age-dysfunctional) immune cells reduced by up to ~37%
• Improvements in cerebral blood flow and cognitive performance in healthy ageing adults

These studies are among the most cited human trials linking HBOT to biological markers associated with ageing and health span.

European human study – inflammation & oxidative balance

A European study in healthy adults undergoing repeated HBOT sessions found:

• No increase in systemic oxidative stress markers
• No elevation in inflammatory cytokines
• Reduced reactive oxygen species activity in immune cells

These findings support HBOT’s suitability for regular wellness use, showing that repeated sessions did not provoke harmful inflammatory responses while modulating oxygen-related pathways.

Together, these findings suggest that hyperbaric oxygen therapy can:

• Reduce systemic inflammation
• Improve vascular oxygen delivery
• Influence cellular ageing markers (telomeres, senescent cells)
• Support cognitive and metabolic health

This is why HBOT is increasingly used as part of longevity-focused wellness programmes rather than as a single intervention.

When used as directed and following proper onboarding, mild hyperbaric oxygen therapy has a strong safety record.

The Epigenedit system includes:

• Controlled pressure ranges
• Medical-grade oxygen delivery
• Safety valves and monitoring systems
• Full user training during installation

Clients are advised to consult a qualified healthcare professional before beginning any new wellness protocol.

Yes. The Epigenedit Hyperbaric Oxygen Chamber is designed for:

• Private homes
• Longevity and wellness clinics
• Performance and recovery environments

Delivery, installation, training, and ongoing support are provided.